Mult Scler 2001 Jun;7(3):165-6
Spitsin S, Hooper DC, Mikheeva T,
Koprowski H
Department of Immunology & Microbiology,
Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
[Medline record in process]
Presence of nitrotyrosine in cells
surrounding plaques indicates that peroxynitrite may be the cause of brain
lesions in multiple sclerosis.
Low levels of uric acid, a natural
scavenger of peroxynitrite, were demonstrated in blood of patients with
multiple sclerosis in comparison with control individuals.
These observations were now extended
to 132 sets of twins with one sibling affected by multiple sclerosis.
In blood of both mono- and dizygotic
twins the uric acid levels were lower in the twin with the disease than
in the healthy twin.
PMID: 11475439, UI: 21366597