More MS news articles for Aug 2001

Frequency and significance of anti-Ro (SS-A) antibodies in multiple sclerosis patients.

Acta Neurol Scand 2001 Aug;104(2):83-7

de Andres C, Guillem A, Rodriguez-Mahou M, Lopez Longo FJ
Departments of Neurology, Immunology and Rheumatology, Hospital General Universitario Gregorio Maranon, Madrid, Spain.


To determine the frequency and significance of antinuclear (ANA), anticardiolipin (ACA) and anti-Ro (SS-A) antibodies in multiple sclerosis (MS) patients.


ANA (indirect immunofluorescence), ACA and anti-Ro (SS-A) antibodies (ELISA) were tested in sera of 42 patients with Poser defined MS and 50 healthy individuals.


High levels of anti-Ro (SS-A) antibodies were found in 3 patients (7%) (vs 0 in the control group). Two of them had normal salivary gland biopsy. Clinical MS form was chronic-progressive in 2 cases and relapsing-remitting in the third one. Ten patients (23%) had low levels of ANA (vs 4%), none of them positive for anti-Ro (SS-A) antibodies. Only 1 patient (2%) with RR clinical form had ACA (vs 0). No clinical or neuroradiological differences with conventional MS patients were observed.


ANA, ACA and anti-Ro (SS-A) antibodies in MS patients indicate an underlying autoimmune disease but our series suggests that they are an epiphenomenon of a more diffuse immunological dysfunction.

PMID: 11493223, UI: 21384452