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More MS news articles for April 2004

Differential cerebellar activation on functional magnetic resonance imaging during working memory performance in persons with multiple sclerosis

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15083441

Arch Phys Med Rehabil. 2004 Apr;85(4):635-9
Li Y, Chiaravalloti ND, Hillary FG, Deluca J, Liu WC, Kalnin AJ, Ricker JH.
Southside Hospital, Bay Shore, NY, USA.

OBJECTIVE:

To explore the potential role of the cerebellum in working memory dysfunction in multiple sclerosis (MS).

DESIGN:

Blood oxygen level dependent functional magnetic resonance imaging (fMRI) was used to examine cerebellar activation during a working memory task.

SETTING:

University-affiliated medical rehabilitation facility.

PARTICIPANTS:

Eight persons with MS and 5 healthy controls.

INTERVENTIONS:

Not applicable.

MAIN OUTCOME MEASURES:

Change in hemodynamic response.

fMRI data were acquired and subsequently analyzed by using Statistical Parametric Mapping.

RESULTS:

Both the control and MS groups showed significantly greater activations in the right cerebellar hemisphere as compared with the left side.

Persons with MS, however, showed no detectable activations in 4 cerebellar substructures that were significantly active in controls (ie, right vermis, right dentate nucleus, right tonsil, cerebellar peduncle).

CONCLUSIONS:

The significantly decreased cerebellar activation in the MS group suggests that the cerebellum may play a role in the working memory impairment observed in MS.