J Clin Invest. 2004 Mar;113(6):788-94
Hafler DA.
Laboratory of Molecular Immunology, Center for Neurologic Diseases,
Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts,
USA.
Multiple sclerosis is a complex genetic disease associated with inflammation in the CNS white matter thought to be mediated by autoreactive T cells.
Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS.
This review discusses new methods to define the molecular pathology of human disease with high-throughput examination of germline DNA haplotypes, RNA expression, and protein structures that will allow the generation of a new series of hypotheses that can be tested to develop better understanding of and therapies for this disease.