Neurology. 2004 Apr 27;62(8):1432-4
Sormani MP, Rovaris M, Valsasina P, Wolinsky JS, Comi G, Filippi M.
Neuroimaging Research Unit, Department of Neurology, Scientific Institute
and University Ospedale San Raffaele, Milan, Italy.
The measurement errors associated with two techniques for brain atrophy assessment in multiple sclerosis (MS) were estimated.
The measurement error of a semiautomated, nonnormalized technique with partial brain coverage was about twofold higher than that of a fully automated, normalized technique with full brain coverage (Structural Image Evaluation of Normalized Atrophy software [SIENA]).
As shown by the analysis of data from a clinical trial of glatiramer acetate, the use of SIENA increases the study power to detect a treatment effect on brain volume changes in MS patients.