All About Multiple Sclerosis

More MS news articles for April 2003

Pharmacogenetic Development of Personalized Medicine: Multiple Sclerosis Treatment as a Model

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12677195&dopt=Abstract

Drug News Perspect 2002 Nov;15(9):558-567
Kirstein-Grossman I, Beckmann JS, Lancet D, Miller A.

The goal of pharmacogenetics is to identify "genetic fingerprints" that may predict a patient's response to pharmaceutical treatment.

The use of pharmacogenetics replaces the trial-and-error strategy, which governs much of our clinical decision-making regarding treatment allocation in current medical practice, with individually tailored therapy.

We review a pharmacogenetic research model, which implements high-throughput single nucleotide polymorphism technology to establish the correlation between drug-responsiveness and genetic polymorphisms of Copaxone(R)-treated multiple sclerosis patients.

Implementation of similar pharmacogenetic approaches may promote the development of personalized medicine in multiple sclerosis as well as in other diseases.