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More MS news articles for April 2003

Anti-interferon-gamma antibodies in the treatment of autoimmune diseases

Curr Opin Mol Ther 2003 Feb;5(1):52-7
Skurkovich B, Skurkovich S.
Brown Medical School, 169 Angell Street, Providence, RI 02912, USA.

Interferon (IFN)-gamma is an important immune regulator in normal immunity.

When IFN gamma production is disturbed, various autoimmune diseases (ADs) can develop, in which we suggest that anti-IFN gamma could have a beneficial effect.

Depending on the cell type in which IFN gamma synthesis is disturbed, different clinical manifestations may result.

We have also proposed to remove tumor necrosis factor (TNF)-alpha, together with certain types of IFNs, to treat various ADs and AIDS, also an autoimmune condition.

Anti-IFN gamma has been tested in several T-helper cell (Th1) ADs, including rheumatoid arthritis (RA), multiple sclerosis (MS), corneal transplant rejection, uveitis, Type I diabetes, schizophrenia (anti-IFN gamma and anti-TNF alpha), and various autoimmune skin diseases (alopecia areata, psoriasis vulgaris, vitiligo, pemphigus vulgaris and epidermolysis bullosa).

A strong, sometimes striking, therapeutic response followed administration of anti-IFN gamma, indicating that it may be a promising therapy for Th1 ADs.