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More MS news articles for April 2003

Apolipoprotein e polymorphism AS a predictor of progression of multiple sclerosis

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12677480&dopt=Abstract

Neurologia 2003 Apr;18(3):146-148
Guerrero A, Bueno V, Hernandez M, Martin-Serradilla J, Carrasco E, Cuadrado I.

Introduction:

During recent years, different studies have proposed that apolipoprotein E e4 can be a predictor of progression in multiple sclerosis.

We aim to evaluate these findings in our country.

Patients and methods:

We studied 42 patients with relapsing remitting or secondary progressive multiple sclerosis, and a disease duration of at least 2 years.

We correlated the presence or absence of e4 allele with markers of progression such as age of onset and diagnosis, disease duration, number of relapses, EDSS at 1, 2, 5 and 10 years, progression index and relapse rate.

Results:

None of the parameters evaluated significantly correlate with e4 allele of the APOE.

Conclusions:

In spite of the limitation due to the small number of patients studied, we cannot confirm that APOE e4 allele is a predictor of progression of disability in multiple sclerosis.