Neurologia 2003 Apr;18(3):146-148
Guerrero A, Bueno V, Hernandez M, Martin-Serradilla J, Carrasco E, Cuadrado I.
During recent years, different studies have proposed that apolipoprotein E e4 can be a predictor of progression in multiple sclerosis.
We aim to evaluate these findings in our country.
Patients and methods:
We studied 42 patients with relapsing remitting or secondary progressive multiple sclerosis, and a disease duration of at least 2 years.
We correlated the presence or absence of e4 allele with markers of progression such as age of onset and diagnosis, disease duration, number of relapses, EDSS at 1, 2, 5 and 10 years, progression index and relapse rate.
None of the parameters evaluated significantly correlate with e4 allele of the APOE.
In spite of the limitation due to the small number of patients studied, we cannot confirm that APOE e4 allele is a predictor of progression of disability in multiple sclerosis.