More MS news articles for April 2002

Proton MR spectroscopic imaging in multiple sclerosis

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11942498&dopt=Abstract

Neuroradiology 2002 Jan;44(1):37-42
Tedeschi G, Bonavita S, McFarland HF, Richert N, Duyn JH, Frank JA.
Istituto di Scienze Neurologiche, Seconda Universita di Napoli, Italy. gioacchino.tedeschi@unina2.it

We studied 24 patients with multiple sclerosis (MS) by proton magnetic resonance spectroscopic imaging (1H-MRSI) to assess the neurochemical pathology of the white-matter lesions (WML) and normal-appearing white matter (NAWM).

Our 1H-MRSI technique allowed simultaneous measurement of N-acetylaspartate (NAA), choline-containing compounds (Cho), and creatine plus phosphocreatine (Cr) signal intensities from four 15-mm slices divided into 0.84 ml single-volume elements.

In WML we found significantly lower NAA/Cr and NAA/Cho ratios and a significantly higher Cho/Cr ratio than in NAWM or control white matter.

In NAWM, NAA/Cr and Cho/Cr were significantly lower than in control white matter.

1H-MRSI was compatible with damage to myelin in WML, and with axonal damage and/or dysfunction in WML and NAWM.

These findings extend data on involvement of NAWM in MS beyond the abnormalities visible on MRI.