Neuroradiology 2002 Jan;44(1):37-42
Tedeschi G, Bonavita S, McFarland HF, Richert N, Duyn JH, Frank JA.
Istituto di Scienze Neurologiche, Seconda Universita di Napoli, Italy. email@example.com
We studied 24 patients with multiple sclerosis (MS) by proton magnetic resonance spectroscopic imaging (1H-MRSI) to assess the neurochemical pathology of the white-matter lesions (WML) and normal-appearing white matter (NAWM).
Our 1H-MRSI technique allowed simultaneous measurement of N-acetylaspartate (NAA), choline-containing compounds (Cho), and creatine plus phosphocreatine (Cr) signal intensities from four 15-mm slices divided into 0.84 ml single-volume elements.
In WML we found significantly lower NAA/Cr and NAA/Cho ratios and a significantly higher Cho/Cr ratio than in NAWM or control white matter.
In NAWM, NAA/Cr and Cho/Cr were significantly lower than in control white matter.
1H-MRSI was compatible with damage to myelin in WML, and with axonal damage and/or dysfunction in WML and NAWM.
These findings extend data on involvement of NAWM in MS beyond the abnormalities visible on MRI.