Elisabeth Bergers, MD 1 *, Joost C. J. Bot, MD 1, Paul van der Valk,
MD 2, Jonas A. Castelijns, MD 1, Geert J. Lycklama A Nijeholt, MD 1, Wouter
KamphorstMD 2, Chris H. Polman, MD 3, Erwin L. A. Blezer, MSc 4, Klaas
Nicolay, PhD 4, Rivka Ravid, PhD 4, Frederik Barkhof, MD 5
1 Departments of Radiology,
2 Pathology, and
3 Neurology, VU Medical Center, Amsterdam, The Netherlands
4 Image Science Institute, University of Utrecht, Utrecht, The Netherlands
5 Netherlands Brain Bank, Amsterdam, The Netherlands
In this study, we compared direct postmortem in situ (whole-corpse) sagittal spinal cord magnetic resonance imaging (1.5T) of 7 multiple sclerosis cases with targeted high-resolution in vitro axial magnetic resonance imaging (4.7T) and histopathology.
On sagittal in situ magnetic resonance imaging, 1 case had a normal spinal cord, 2 had only focal lesions, 3 had a combination of focal and diffuse abnormalities, and 1 had only diffuse abnormalities.
All spinal cords showed abnormalities on high-resolution magnetic resonance
imaging and histopathology, confirming the existence of diffuse cord changes
as genuine multiple sclerosis-related abnormalities while highlighting
the limited resolution of in vivo magnetic resonance imaging.
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