Trends Immunol 2002 Apr 1;23(4):180-1
De Fanti BA, Lamas O, Milagro FI, Martinez-Anso E, Martinez JA.
Dept of Physiology and Nutrition, University of Navarra, c/Irunlarrea 31008, (Navarra), Pamplona, Spain
The neuroendocrine and immune systems are linked through a complex bi-directional network, in which hormones modify immune function, and the immune system, through the action of cytokines, affects neuroendocrine responses involved in the maintenance of body homeostasis.
The adipocyte-derived, peptide hormone leptin is a pleiotropic molecule belonging to the helical cytokine family.
On pp. 182-187, Matarese et al. suggest the possibility of new leptin-based therapeutic strategies for the treatment of both infection and autoimmune disease.