More MS news articles for April 2002

Interferon type I downregulates human parainfluenza virus type 3-induced major histocompatibility complex class II expression

Viral Immunol 2002;15(1):85-93
Gao J, De BP, Banerjee AK.
Department of Virology, Lerner Research Institute, The Cleveland Clinic Foundation, Ohio 44195, USA.

Human parainfluenza virus type 3 (HPIV3) induces major histocompatibility complex (MHC) class II expression in a signal transducer and activator of transcription-1 (STAT1)- and class II transactivator (CIITA)-independent manner.

Interferon (IFN)-gamma, the potent inducer of MHC class II, on the other hand, requires both STAT1 and CIITA in the induction process.

IFN-alpha/beta has been shown to inhibit the IFN-y-induced expression of MHC class II by targeting a step(s) downstream of CIITA.

Here we report that IFN-alpha/beta also inhibits the CIITA-independent expression of HPIV3-induced MHC class II.

The inhibitory role of IFN-alpha/beta on HPIV3-induced MHC class II was confirmed by using anti-IFN-alpha/beta antibody and mutant cell lines defective in the IFN signaling components STAT1 and STAT2.

IFN-alpha/beta inhibits virus-induced MHC class II expression just as it does IFN-gamma-induced MHC class II.

The inhibition by IFN-alpha/beta of MHC class II expression may play a regulatory role in virus induced autoimmune disease mediated by MHC class II aberrant expression.