Human Immunology, Vol. 63 (4) (2002) pp. 281-285
Brigit A. de Jong a, Rudi G.J. Westendorp b, Joyce Eskdale c, Bernard M.J. Uitdehaag d and Tom W.J. Huizinga * e
a Department of Clinical Epidemiology (B.A.d.J.)Glasgow, Scotland, United Kingdom
b Department of Internal Medicine (R.G.J.W.)Glasgow, Scotland, United Kingdom
c Department of Surgery (J.E.), University of Glasgow, Glasgow, Scotland, United Kingdom
d Department of Neurology (B.M.J.U.), VU Medical Center, Amsterdam, The Netherlands
e Department of Rheumatology (T.W.J.H.), LUMC, Leiden, The Netherlands
Interleukin-10 (IL-10) secretion affects the inducibility of experimental autoimmune encephalomyelitis and the outcome of multiple sclerosis (MS).
Here, we report that a G to A polymorphism in the IL-10 promoter at position -2849 is significantly associated with low IL-10 production.
The frequency of this polymorphism is lower among patients with primary
progressive compared with patients with relapse-onset MS and control persons.
© 2002 American Society for Histocompatibility and Immunogenetics