More MS news articles for April 2002

Quantitative functional measures in MS: What is a reliable change?

Neurology 2002;58:1294-1296
S. R. Schwid, MD, A. D. Goodman, MD, M. P. McDermott, PhD, C. F. Bever, MD and S. D. Cook, MD
From the Departments of Neurology (Drs. Schwid, Goodman, and McDermott) and Biostatistics (Dr. McDermott), University of Rochester Medical Center, NY; Department of Neurology (Dr. Bever), University of Maryland, Baltimore; and Department of Neurology (Dr. Cook), University of Medicine and Dentistry of New Jersey, Newark.

As a first step toward understanding which changes should be considered as meaningful, the authors assessed the reliability of quantitative functional tests on 5 consecutive days in 63 patients with MS, determining the range of measurement variability present when patients are clinically stable.

Time to walk 25 feet (T25FW) and the 9-hole peg test (9HPT) varied by <20% of individual mean scores on repeated testing.

Therefore, a 20% change on these tests can be considered to be the threshold that reliably indicates a true change in function for an individual.

© 2002 American Academy of Neurology