S. R. Schwid, MD, A. D. Goodman, MD, M. P. McDermott, PhD, C. F. Bever, MD and S. D. Cook, MD
From the Departments of Neurology (Drs. Schwid, Goodman, and McDermott) and Biostatistics (Dr. McDermott), University of Rochester Medical Center, NY; Department of Neurology (Dr. Bever), University of Maryland, Baltimore; and Department of Neurology (Dr. Cook), University of Medicine and Dentistry of New Jersey, Newark.
As a first step toward understanding which changes should be considered as meaningful, the authors assessed the reliability of quantitative functional tests on 5 consecutive days in 63 patients with MS, determining the range of measurement variability present when patients are clinically stable.
Time to walk 25 feet (T25FW) and the 9-hole peg test (9HPT) varied by <20% of individual mean scores on repeated testing.
Therefore, a 20% change on these tests can be considered to be the threshold
that reliably indicates a true change in function for an individual.
© 2002 American Academy of Neurology