Curr Neurol Neurosci Rep 2001 May;1(3):249-56
Kalman B, Lublin FD.
Department of Neurology, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1137, New York, NY 10029-6574, USA.
The aim of this review is to highlight recent observations concerning the pathogenesis of acute and chronic inflammatory demyelinating diseases in the central nervous system.
Without attempting to provide a didactic classification or a complete survey, we emphasize the discriminative nature of new clinical, imaging, and immunopathologic data, which, even in the absence of specific molecular markers, modify our views about the nosologic relations among these overlapping clinicopathologic entities.
In the light of new findings, multiple sclerosis may represent a spectrum of demyelinating diseases rather than a single entity.