1 April 2002, vol. 8, no. 2, pp. 108-114(7)
Ingle GT; Stevenson VL; Miller DH; Leary SM; Rovaris M; Barkhof F; Brochet B; Dousset V; Filippi M; Montalban X; Kalkers NF; Polman CH; Rovira A; Thompson AJ
 NMR Research Unit, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
 Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, University of Milan, Milan, Italy
 Department of Diagnostic Radiology, Free University Hospital, Amsterdam, The Netherlands
 Departement de Neurologie CHU-Hôpital Pellegrin, Bordeaux, France
 Service de Neurologie, CHU-Hôpital Pellegrin, Bordeaux, France
 Unitat de Ressonancia Magnetica, Centre Vall d'Hebron, Institut de Diagnostic per la Imatge, Pg. Vall d'Hebron 119– 129, 08035 Barcelona, Spain
This study documents changes in clinical and magnetic resonance imaging (MRI) characteristics in a large cohort of patients with primary and transitional progressive multiple sclerosis (PP and TPMS) over 2 years.
Patients with PPMS and TPMS were recruited from six European centres and underwent clinical and MRI examination at three time points: baseline, year one and year two.
Of the 190 patients recruited clinical data were available on 125 patients (66%, five centres) and MRI data were available on 113 patients (59%, four centres) at 2 years.
Significant increases were seen in T2 load and T1 hypointensity, while brain and cord volume decreased.
In PPMS significantly higher lesion loads were found in those who presented with non-cord syndromes when compared to cord presentation and there was a trend to greater brain atrophy in those who deteriorated clinically over the course of the study compared to those who remained stable.
Significant cord atrophy was only seen in those with a cord presentation.
Measurable changes in MRI parameters can be detected in PPMS patients over a relatively short period of time.
MRI quantification is likely to be useful in elucidating disease mechanisms
in PPMS and in the execution of clinical trials.
© 2002 ingenta