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Th1 immunity

Th1/2 immunity is accepted although it is now considered to be a spectrum. Therefore a response can be thought of as biased towards either Th1 or Th2 assuming the predominant cytokine driving that response is IL-12/IFN or IL-4 respectively. Some responses can have elements of both cytokine profiles and a term I have often come across for this is Th0 (ie both IL-4 and IFN are produced in significant ammounts). More recently it has become a little more complicated with the identification of regulatory T-helper cells. These are currenly defined as Th3 (producing TGF-beta1) and Tr1 (producing IL-10). Another subset of regulatory cells that mediate their supressive effects through cell contact rather than cytokines have been identified. These supressive CD4+CD25+ cells are apparently anergic (although I always though anergy was defined as 'functional unresponsiveness'). If you have a look through the December issues of Current Opinion in Immunology from the past few years there are some excellent reviews on this topic (try biomednet for free back issues ). Anyhow to cut a long story short Th1/2 immunity is still accepted however it is an oversimplification of a more complex system.

Th1 immunity links:
HON Allergy Glossary TH1/TH2
Role of Th1 and Th2 cells in autoimmune demyelinating disease

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